Cell Line Development Scientist

Profile

Bristol-Myers Squibb is a global Biopharma company committed to a single mission: to discover, develop, and deliver innovative medicines focused on helping millions of patients around the world in disease areas such as oncology, cardiovascular, immunoscience and fibrosis.

Join us and make a difference. We hire the best people and provide them with a work environment that places a premium on diversity, integrity, collaboration and personal development. Through a culture of inclusion, we create a better, more productive work environment. We believe that the diverse experiences and perspectives of all our employees help to drive innovation and transformative business results.

Bristol-Myers Squibb is a global biopharmaceutical company whose mission is to discover, develop and deliver innovative medicines that help patients prevail over serious diseases.

One shared journey is moving us forward at Bristol-Myers Squibb. Around the world, we are passionate about making an impact on the lives of patients with serious disease. Empowered to apply our individual talents and ideas so that we can learn and grow together. Bristol-Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees the resources to pursue their goals, both at work and in their personal lives.

Bristol-Myers Squibb Biologics Development has Cell Line Development and ‘Omics organization comprising Molecular biology, Cell Line Development, and Multi-Omics, is co-located with Upstream and Downstream Process development, Process Analytics, and Analytical Development organization in New Brunswick and Summit sites in New Jersey. BMS New Jersey sites are part of New Jersey’s “Biopharmaceutical Life Sciences Cluster,” a concentrated area of biotechnology, medical device, and pharmaceutical companies.

Position Description:

Reporting to the Head of Cell Line Development sub-team in BMS-Summit, NJ site, the successful candidate will focus on the development of mammalian cell lines in the production of monoclonal antibody and other types of recombinant proteins, including bi-specific antibody, fusion protein, and antibody drug conjugates, for clinical and commercial manufacturing. This scientist will work closely with other functional groups such as R&D, molecular biology, upstream process development and process development analytics.

Key Responsibilities:


Lead cell line development project and performs key activities associated with production cell line development including transfection, selection, single cell cloning, high throughput screening, characterization of clonal cell lines using scale-down models, cell banking, and cell line stability studies.

Develop and optimize new protein expression platform including designing, constructing, and evaluating novel expression vectors and expression system.

Evaluate and introduce innovative technologies to improve cell line development process and therapeutic protein production

Perform and develop immunoassays such as Octet, ELISA, and flow cytometry analysis.

Work closely with other functional teams, Upstream Process Development, Downstream purification, Analytical Development, and cross-function CMC project team to support development activities.

Managing development projects with external partners and outsourcing activities.

Create written technical reports and presents and publish data at internal and public forums.

Additional responsibilities as assigned.


Qualifications:


PhD in Biological Sciences, Molecular Biology, Biochemical Engineering, or relevant discipline and 0-2 years of relevant experience, MS with 4-6 years relevant experience, BS with 6-8 years of relevant experience.

Hands-on experience with generating high producing CHO production cell line is required.

Experience with DNA cloning, vector construction and design, and genetic characterization of production cell banks is required. Experience with operating ambr microbioreactor and bench scale bioreactor will be a plus

Experience with immunological assays such as Octet assay, ELISA, SDS-PAGE, Western blot, and FACS analysis is required.

Experience with bioinformatics and omics approach is preferred

Well versed with DOE and statistical analysis

Experience with gene targeting and genome editing technologies will be a plus.

Proven record on publication in peer reviewed journals and presentation in conference.

The candidate must be well organized and have excellent oral and written communication skills.


Bristol-Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees the resources to pursue their goals, both at work and in their personal lives.

Bristol-Myers Squibb is an equal opportunity employer. Qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or protected veteran status.

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