Sr. Research Investigator Proteomics Chemical Biology/Chemo Proteomics

Profile

Bristol-Myers Squibb is a global Biopharma company committed to a single mission: to discover, develop, and deliver innovative medicines focused on helping millions of patients around the world in disease areas such as oncology, cardiovascular, immunoscience and fibrosis.

Join us and make a difference. We hire the best people and provide them with a work environment that places a premium on diversity, integrity, collaboration and personal development. Through a culture of inclusion, we create a better, more productive work environment. We believe that the diverse experiences and perspectives of all our employees help to drive innovation and transformative business results.

Summary

Bristol Myers Squibb is a global biopharmaceutical company whose mission is to discover, develop and deliver innovative medicines that help patients prevail over serious diseases.

One shared journey is moving us forward at Bristol Myers Squibb. Around the world, we are passionate about making an impact on the lives of patients with serious disease. Empowered to apply our individual talents and ideas so that we can learn and grow together. Driven to make a difference, from innovative research to hands-on community support. Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees the resources to pursue their goals, both at work and in their personal lives.

Job Description

We seek an experienced, talented, highly motivated and detail-oriented Proteomics Researcher with proven track record to join the Discovery & Translational Proteomics group within the Research & Early Development organization at BMS. This is a laboratory based position, reports directly to the Head of Discovery & Translational Proteomics within the Small Molecule Drug Discovery organization. The candidate is expected to work effectively in a highly collaborative matrixed environment and interface with Oncology, Immunoscience, Neuroscience, Cardiovascular, and Fibrosis discovery biology areas, chemistry as well as translational research investigators and champion proteomics methodologies / modalities to help solve complex drug discovery & translational research questions.


The candidate needs to have sufficiently deep understanding of biochemistry and biology to help articulate the problem statement, communicate with key stakeholders and bridge across matrixed teams.

A demonstrated ability to convert datasets to usable knowledge and utilize it to support the program progression across the Drug Discovery Translational Research continuum.

Deep familiarity with other “omics” and experience in building synergies to achieve integrative omics outcomes.

An established track record in articulating the need for proteomics as well as successfully applying proteomics to drug discovery and translational space.

A demonstrated ability in applying activity-based and chemical proteomics to elucidate receptor ligand interactions, target deconvolution, drug-proteome interactions for, specificity as well as on/off target assessments and modulation protein-protein interactions with chemotype intervention.

Deep experience developing, deploying and utilizing innovative proteomics techniques / workflows (emphasis on Chemical Proteomics) to characterize complex proteomes (including post-translational proteomes) to enable discovery, translational activities is absolutely necessary.

Experience with proteome level post-translational modification analyses (e.g. glycosylation, acetylation/methylation) is highly desirable.

Deep “hands on” experience with proteomics analytical instrumentation (latest generation, nano-chromatography and mass spectrometry), associated workflows, and data processing software packages is a must.

The candidate is expected to spend at least 60% of their time in the proteomics lab and perform experiments alongside their team as well as interface with the larger proteomics team.

Significant experience and in-depth knowledge of proteomics design of experiments, LC/MS proteomics data processing and subsequent data analyses. Detailed understanding of proteomics related bioinformatics and associated software packages is required.

Experience and ability to successfully interface with bioinformaticians and biostatisticians is an absolute must to enable in-depth proteomics data analysis and achieve superlative outcomes for programs.

Hands on experience with automation and laboratory instrument data management would is highly desirable.

Proficiency in applying classical protein biochemical techniques (protein fractionations, chromatography etc.) and most up to date proteomics techniques is expected and familiarity with basic cell culture techniques and standard molecular biology techniques is highly desirable.

Additionally, experience with handling human as well as animal biomatrices (including tissues, plasma …) is highly desirable.

Overall, excellent lab skills and lab etiquette are crucial and required to be successful in this position.

The candidate must have expertise with compiling and reviewing lab work practices and maintain regular scientific records in terms of laboratory notebooks.

The candidate should be proficient with workplace software tools (word processing, excel, presentation etc.).


Qualifications


Ph.D. (minimum of 4-10 yrs) in Life Sciences, Biochemistry, Analytical Chemistry or related field is preferred including relevant proteomics experience.

Scientific creativity, innovation and resilience are absolutely necessary to be successful in this position.

A track record of scientific productivity in proteomics area documented in high impact peer reviewed journals is necessary.

A demonstrated ability to manage teams and contribute strategically to areas of discovery & translational research.

The candidate should have a strong interest in drug discovery, translational, and clinical research.

The individual should possess ability to handle multiple projects in parallel, closely collaborate & matrix with scientists within the group and with investigators across Research and Early Development organization.

The candidate is required to have effective organization and presentation skills; be reliable, highly motivated, have strong interpersonal communication skills and embrace working in a team/matrix environment.

Ability to effectively manage scientific staff by articulating a vision, prioritizing work and supervising studies is highly desirable.

The candidate should possess strong personal attributes of integrity, perseverance in face of challenges, and ability to tackle highly complex challenges.


Bristol-Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees the resources to pursue their goals, both at work and in their personal lives.

Bristol-Myers Squibb is an equal opportunity employer. Qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or protected veteran status.

Company info

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