Principal Scientist In Vivo Pharmacology

Profile

Bristol-Myers Squibb is a global Biopharma company committed to a single mission: to discover, develop, and deliver innovative medicines focused on helping millions of patients around the world in disease areas such as oncology, cardiovascular, immunoscience and fibrosis.

Join us and make a difference. We hire the best people and provide them with a work environment that places a premium on diversity, integrity, collaboration and personal development. Through a culture of inclusion, we create a better, more productive work environment. We believe that the diverse experiences and perspectives of all our employees help to drive innovation and transformative business results.

The Tumor Microenvironment Thematic Research Center (TME TRC) is focused on developing therapeutic targets at the intersection of tumor, stromal and immune biology within the TME with the goal of enhancing responsiveness to checkpoint blockade and targeted therapies. Comprising of scientists across multiple disciplines we are responsible for the biology and translational science necessary to support drug development from target identification through to first in human studies.

We seek an experienced, creative Principal Scientist in the field of Immune Oncology/Oncology to join our In Vivo Pharmacology group within the Tumor Microenvironment Thematic Research Center at Bristol-Myers Squibb in Redwood City, California. The successful candidate will play a leading role in the development of advanced models of cancer and the discovery and evaluation of novel therapeutics for the treatment of cancer leveraging both cancer cell and immune intrinsic biology.

The Principal Scientist will lead and mentor a group of scientists responsible for developing and executing in vivo strategies using a wide range of animal models including syngeneic, GEMM, CDX, PDX and humanized tumor models. Characterize and develop small and large molecule therapeutics in close collaboration with partner lines (discovery biology, medicinal chemistry, MAP/DMPK, preclinical safety, translational research, and early clinical development) as an integral member of drug discovery teams. The qualified candidate is a highly motivated, interactive, and team-oriented individual that possesses the ability to work across a highly matrixed environment to provide technical and scientific in vivo pharmacology expertise to advance a variety of drug discovery programs from target identification/validation, to IND enabling activities and ultimately to clinical Proof of Concept in patients. Ideal candidates will possess excellent communication and leadership skills with a strong commitment to scientific objectivity and excellence.

Responsibilities:


Working closely with project teams and key stakeholders, lead the development of scientific in vivo strategies and serve as in vivo pharmacology lead on several drug discovery programs.

Supervision and scientific mentorship of 4-5 scientists (PhD and BS/MS level).

Design, conduct and analyze in vivo studies to evaluate and establish Efficacy/PK/PD relationships.

Manage and prioritize internal resource allocation and external collaboration if necessary.

Develop novel animal models that more closely mimic human cancer to answer mechanistic questions, discover and validate therapeutic targets, and screen/profile drug candidates.

Interact closely with colleagues in Translational Research and Early Clinical Development to establish biomarker strategies and play a leadership role in developing preclinical data sets to inform patient stratification and rational combination strategies for novel therapeutics.

Serve as oncology biology and drug discovery expert on external collaborations and alliances.

Compliance with IACUC and AALAC regulations.

Interpretation, documentation and presentation of experiments within a multidisciplinary team environment. Ensure that projects have all critical in vivo data to enable project stage dependent decisions. Responsible for contribution to relevant in vivo sections of stage gate reports and regulatory documents i.e. IND filings.

Publication of results in scientific peer-reviewed journals and presentations at internal, national, and international meetings.


Qualifications and Requirements:


PhD in cancer biology, immunology with 8-10 years of relevant industry experience and demonstrated expertise in cancer biology, oncogenic signaling pathways, or immuno-oncology is required.

Demonstrated expertise developing focused in vivo strategies and utilizing PK/PD/efficacy data to drive lead optimization & characterization as well as translational strategies to enable early clinical development.

Excellent leadership and mentorship skills, including experience leading a successful team of research scientists and demonstrated ability to mentor junior PhDs and associates.

Excellent interpersonal and communication skills to interact effectively with internal and external colleagues fostering a collaborative workplace environment.

Hands on in vivo skills (dosing, tissue/blood collection, surgery).

Demonstrated expertise in in vitro/ex vivo assays including qPCR, MSD/ELISA and flow cytometry is a plus.

Competitive candidates are expected to have a strong track record of independent and innovative research as evidenced by publications in top tier peer-reviewed journals.


Travel Required


Local and international travel for conferences and meetings may be required depending on project needs up to 5-10% of the time.


Bristol-Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees the resources to pursue their goals, both at work and in their personal lives.

Bristol-Myers Squibb is an equal opportunity employer. Qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or protected veteran status.

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