Principal Scientist Gene Editing Platform Development

Profile

Why Join Intellia? 

Our mission is to develop curative genome editing treatments that can positively transform the lives of people living with severe and life-threatening diseases. 

Beyond our science, we live our four core values: One, Explore, Disrupt, Deliver and feel strongly that you can achieve more at Intellia. We have a single-minded determination to excel and succeed together. We believe in the power of curiosity and pushing boundaries. We welcome challenging thoughts and imagination to develop innovative solutions. And we know that patients are counting on us to make the promise a reality, so we must maintain high standards and get it done. 

We want all of our people to go beyond what is possible. We aren’t constrained by typical end rails, and we aren’t out to just “treat” people. We’re all in this for something more. We’re driven to cure and motivated for change. Just imagine the possibilities of what we can do together.   

How you will Achieve More with Intellia:

We are looking for a Principal Scientist to join our energetic, exciting and cross-functional team. You will be responsible for helping drive DNA writing-based genome editing technologies towards human therapeutics. You will evaluate new technologies and approaches to support Intellia’s Gene Editing Platform Development. Additional role responsibilities include:

• Independently design, execute and troubleshoot high throughput experiments to optimize gene editing efficiency in different mammalian immortal cell lines and primary cells via different delivery methods (Lentivirus, AAV, Lipid nanoparticles etc.)

• Act as a liaison and collaborate in a matrixed organization to optimize gene editing efficiency in different animal models

• Document results in a timely manner in electronic notebooks and present findings to cross-functional teams

• Analyze and synthesize results to assess future directions

• Keep up to date with primary literature and contribute to Intellia’s Gene Editing Platform strategy

• Opportunity to lead a small team (1-2 direct reports)

About You:

Do you describe yourself as high-energy and goal-driven? Our ideal candidate will have extensive experience with different CRISPR-based gene editing technologies. Expertise with a broad spectrum of molecular biology, cell biology, and biochemical methodologies are also required. Additional role requirements include:

• Organized, driven self-starter with demonstrated problem-solving skills and the ability to work collaboratively within a broader cross-functional team

• PhD in Biochemistry, Biophysics or Cellular and Molecular biology with 5-7 years of post-PhD Industry experience. Strong candidates with Bachelors (10-12 years) or Masters (8-10 years) in related disciplines will also be considered.

• Extensive knowledge of the CRISPR landscape and/or polymerases, experience in mammalian genome editing with CRISPR/Cas9 or similar technologies

• Experience with rational design and/or directed evolution of proteins and/or nucleic acids

• Experience overseeing and/or developing junior scientists

Meet your future team:

The Gene Editing Platform Development team, within the Platform Innovation function, is a cohesive group of fun and energetic individuals. We have a common goal of making a difference by developing new and improved CRISPR-based gene editing tools for curative human therapeutics. You will report directly to the Associate Director, Platform Innovation. This hiring manager leads/co-leads engineering efforts geared towards expanding Intellia’s gene editing toolbox to potentially unlock currently inaccessible disease indications. Given the breadth of activities within this team, the candidate will have the opportunity to explore both new and established projects across Intellia’s in vivo and ex vivo platforms and programs. 

The team is currently working mostly onsite to execute workflows in a wet-lab environment. Therefore, we require the candidate to be currently local to Cambridge MA, or open to relocating.  While much of the day-to-day operations require wet-lab work, our team is focused on building not just technical expertise but fostering an environment for growth of scientists interested in a career in biotech and chemistry.  If you join our team, you can expect to join a hardworking and collaborative environment. We look forward to fostering your skills, learning from your experiences, and building a larger team that will make a difference in patient’s lives.

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Covid-19 Vaccination Policy: All Intellia employees, regardless of work location, must be fully vaccinated for COVID-19. This requirement includes a booster dose once eligible. Requests for exemption for medical or sincerely held religious beliefs will be considered.

EEOC Statement: Intellia believes in a diverse environment, and is committed to equal employment opportunity for all its employees and qualified applicants. We do not discriminate in recruitment, hiring, training, promotion or any other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, marital or veteran status, disability, or any other legally protected status. Intellia will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

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