Associate Research Scientist HTP Assays and Protein Expression and Purification

Profile

Bristol-Myers Squibb is a global Biopharma company committed to a single mission: to discover, develop, and deliver innovative medicines focused on helping millions of patients around the world in disease areas such as oncology, cardiovascular, immunoscience and fibrosis.

Join us and make a difference. We hire the best people and provide them with a work environment that places a premium on diversity, integrity, collaboration and personal development. Through a culture of inclusion, we create a better, more productive work environment. We believe that the diverse experiences and perspectives of all our employees help to drive innovation and transformative business results.

The Discovery Biotherapeutics team at Bristol-Myers Squibb seeks to understand the structure and function of complex molecules such as antibodies and endogenous proteins in order to optimize their utility as therapeutic agents. We collaborate with biology and translational scientists imbedded in the Thematic Research Centers in order to prosecute Targets and Biological pathways with disease modifying potential. By using a blend of internal and external technologies and capabilities, we work to discover and deliver first-in-class as well as best-in-class molecules that warrant clinical evaluation for patient benefit.

Position Summary:

We are seeking a highly skilled, detail-oriented Associate Research Scientist to join the Antibody Platform Technology team working with automated protein expression, purification, and assays to develop therapeutic and tool antibodies. Using her/his skill set, the candidate will work with the team to manage, optimize, and run High Throughput protein, expression, purification, and assay experiments on multiple automation systems.

Responsibilities:


High throughput expression, purification, and characterization of antibodies using laboratory automation
Assist in identifying, developing, and validating a variety of biological assays used to support the development of therapeutic and tool antibodies
Assist in the optimization of high throughput expression, purification, and assays automation systems used to support the development of therapeutic and tool antibodies
Characterize assays for their throughput, strengths and weaknesses and suggest improvements or alternatives to drive innovation and continual improvements
Work with the process owners to run day-to-day assays and to identify areas of improvement
Analyze and track data over time to identify systematic errors and drift


Requirements:


BS degree with 3-5 years of relevant experience in Biochemistry, Molecular or Cell Biology, or related field
Strong knowledge of present and next generation antibody discovery, small scale expression, purification, and screening
Experience using automation systems and liquid handlers
Demonstrated experience with techniques used to measure antibody-antigen interaction (ie. ELISA, FACS, HTRF, Octet binding)
Knowledge of cell based assays is a plus
Demonstrated independence in experimental design, execution, data analysis, and troubleshooting
Effective communication of work, plans, and progress using written and verbal communication
Ability to efficiently manage and prioritize multiple projects and coordinate material exchanges with end users
Attention to detail with excellent organizational skills and accurate record keeping
Experience using Spotfire data visualization tools for large data sets is preferred


Bristol-Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees the resources to pursue their goals, both at work and in their personal lives.

Company: Bristol-Myers Squibb

Req Number: R1526381_EN

Updated: 2020-06-16 00:00:00.000 UTC

Location: Redwood City,California

Bristol Myers Squibb is an equal opportunity employer. Qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, disability, protected veteran status, pregnancy, citizenship, marital status, gender expression, genetic information, political affiliation, or any other characteristic protected by law.

Company info

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