Procees Engineer II Cell Processing Technology Development

Profile

Bristol-Myers Squibb is a global Biopharma company committed to a single mission: to discover, develop, and deliver innovative medicines focused on helping millions of patients around the world in disease areas such as oncology, cardiovascular, immunoscience and fibrosis.

Join us and make a difference. We hire the best people and provide them with a work environment that places a premium on diversity, integrity, collaboration and personal development. Through a culture of inclusion, we create a better, more productive work environment. We believe that the diverse experiences and perspectives of all our employees help to drive innovation and transformative business results.

Job Description:

Bristol-Myers Squibb is a global Biopharma company committed to a single mission: to discover, develop, and deliver innovative medicines focused on helping millions of patients around the world in disease areas such as oncology, cardiovascular, immunoscience and fibrosis.

Join us and make a difference. We hire the best people and provide them with a work environment that places a premium on diversity, integrity, collaboration and personal development. Through a culture of inclusion, we create a better, more productive work environment. We believe that the diverse experiences and perspectives of all our employees help to drive innovation and transformative business results.

CAR-T cell therapies are a revolutionary advance in medical treatment, but the success of these new treatments depends upon our ability to develop robust and affordable production methods. As part of our manufacturing development team, we are seeking a highly capable and independent Process Engineer II to work with a multidisciplinary group of engineers and scientists to support the development of novel, multi-scale cell washing and processing platforms. The successful candidate will work to develop and implement technologies that provide robust cell washing, processing and recovery for autologous and allogeneic Cell Therapy products. The candidate will be responsible for independently developing automated cell processing workflows and methods, and integrating developed technologies within current Cell Therapy process unit operations. This role requires direct hands-on experience with cell washing instrumentation and in-depth method and instrument troubleshooting skills. The candidate will additionally be expected to execute T cell culture experiments using a combination of scale-down models and manufacturing scale technologies and equipment.

The successful candidate will:


Partner with colleagues in Platform and Technology development teams, as well as external suppliers to design, develop and implement innovative cell washing and processing equipment

Execute feasibility testing of emerging technologies and engage with key stake holders to ensure technology development alignment with Cell Therapy program requirements

Collaborate with internal partners to experimentally develop methods for cell processing applications, analyze results and draft technical reports to communicate key conclusions

Support cell washing/processing equipment and single-use systems integration within Cell Therapy process unit operations

Compile comprehensive data package, operating procedures, and technical documentation to support technology implementation within development and manufacturing organizations


Basic Qualifications:


M.Sc in Chemical or Biological Engineering with 2-3 years, or B.Sc with 4-6 years, of relevant technology development experience within the Cell and Gene Therapy or Biologics industry

Hands-on experience with development and operationalization of cell processing equipment to support Cell Therapy applications such as cell washing, gene transfer, formulation, media exchange and volume reduction

Experience with equipment support and troubleshooting

Demonstrated independence in experimental design, execution, data analysis and troubleshooting

Experience with tissue culture, preferably with primary cells


Preferred Qualifications:


Leadership of technical team

Experience in use of automated control, preferably DeltaV

Experience with cell selection, T cell activation, lentiviral transduction, and cryopreservation

Experience with Microsoft Excel, Prism (Graphpad), and statistical programs for data analysis (JMP)

Excellent technical writing and oral communication skills

Driven individual that works well independently and within a multidisciplinary team


Bristol-Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees the resources to pursue their goals, both at work and in their personal lives.

Bristol-Myers Squibb is an equal opportunity employer. Qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or protected veteran status.

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