Associate Director Drug Discovery

Profile

Bristol-Myers Squibb is a global Biopharma company committed to a single mission: to discover, develop, and deliver innovative medicines focused on helping millions of patients around the world in disease areas such as oncology, cardiovascular, immunoscience and fibrosis.

Join us and make a difference. We hire the best people and provide them with a work environment that places a premium on diversity, integrity, collaboration and personal development. Through a culture of inclusion, we create a better, more productive work environment. We believe that the diverse experiences and perspectives of all our employees help to drive innovation and transformative business results.

Associate Director, Drug Discovery, BMS

The successful candidate will join the drug discovery group at the Mechanisms of Cancer Resistance Thematic Research Center at Bristol-Myers Squibb in Cambridge, MA. The individual will aide in the discovery and advancement of novel therapeutics for the treatment of cancer targeting tumor intrinsic biology including oncogenic signaling and DNA damage response pathways.

The qualified candidate will be a highly motivated, interactive, and creative individual that possesses the ability to work across a highly matrixed environment to advance drug discovery programs from target identification/validation, to IND enabling activities and ultimately to Proof of Concept in patients. Extensive experience leading small molecule, drug discovery programs through lead optimization and characterization will be highly valued.

The candidate will lead a group of scientists responsible for developing and executing strategies using a wide range of in vitro and in vivo models to enable mechanism of action studies. The candidate will also have the opportunity to lead multi-disciplinary drug discovery teams, and will be expected to work seamlessly with colleagues across BMS Thematic Research Centers and collaborators in medicinal chemistry, MAP/DMPK, preclinical safety, pharmacology, translational research, and early clinical development.

Job Qualifications and Requirements


PhD with at least 8 years of relevant industry experience and demonstrated expertise in cancer biology, oncogenic signaling pathways, or DNA damage response pathways is required.

Demonstrated expertise developing focused strategies and utilizing PK/PD/efficacy data to drive small molecule lead optimization & characterization as well as translational strategies to enable early clinical development.

The candidate is expected to have excellent leadership and mentorship skills, including experience leading a high functioning team of research scientists and demonstrated ability to supervise, mentor and develop junior PhDs and associates.

Experience leading multi-disciplinary drug discovery teams is desired.

Excellent interpersonal and communication skills with the ability to interact effectively with internal and external colleagues is required.

Demonstrated expertise in in vitro/ex vivo assays including qPCR, MSD/ELISA and flow cytometry is needed.

Competitive candidates are expected to have a strong track record of independent and innovative research as evidenced by publications in top tier peer-reviewed journals.


Job Responsibilities include:


Working closely with project teams and key stakeholders, lead the development of strategies from target concept to Proof of Concept in patients, including target validation, lead optimization & characterization, and development of translational strategies.

Work closely with colleagues in Translational Research and Early Clinical Development to establish biomarker strategies and play a leadership role in developing preclinical data sets to inform patient stratification and rational combination strategies for novel therapeutics.

Develop novel mechanism-of action models that more closely mimic human cancer to enable the discovery of novel biology and answer mechanistic questions, discover and validate therapeutic targets, and screen/profile drug candidates.

Serve as oncology biology and drug discovery expert on external collaborations and alliances.

Provide mentorship to junior PhD scientists and associates in the team.

Work as a member of a diverse and motivated team of researchers from across Discovery Oncology and key internal and external collaborators.


Bristol-Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees the resources to pursue their goals, both at work and in their personal lives.

Bristol-Myers Squibb is an equal opportunity employer. Qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability or protected veteran status.

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