Senior Scientist Biotherapeutics

Profile

At Bristol Myers Squibb, we are inspired by a single vision - transforming patients' lives through science.In oncology, hematology, immunology and cardiovascular disease - and one of the most diverse and promising pipelines in the industry - each of our passionate colleagues contribute to innovations that drive meaningful change. We bring a human touch to every treatment we pioneer. Join us and make a difference.

The Discovery Biotherapeutics team at BMS seeks to understand the structure and function of complex molecules such as antibodies and endogenous proteins in order to optimize their utility as therapeutic agents. We collaborate with biology and translational scientists imbedded in the Thematic Research Centers in order to prosecute Targets and Biological pathways with disease modifying potential. By using a blend of internal and external technologies and capabilities, we work to discover and deliver first-in-class as well as best-in-class molecules that warrant clinical evaluation for patient benefit.

Position Summary:

The Discovery Biotherapeutics group at Bristol Myers Squibb is seeking a highly motivated and innovative Senior Scientist with demonstrated expertise in biologics drug discovery to join our Binder Generation group. The successful candidate is expected to utilize internal and external resources to implement antibody/protein technologies and identify therapeutic candidates and tool molecules. A track record in high-throughput screening assay development, antibody function, and immunological/effector activity screening will be highly valued. The qualified candidate will provide screening and functional assays data needed for triage and lead selections. Research responsibilities will also include generation and characterization of antibodies and tools/reagents for validation in new target biology, proof-of-concepts, and participate in technology development teams to create novel approaches in antibody-based biologics . The candidate will also work closely with core teams of the BMS Thematic Research Centers in supporting immuno-oncology, oncogenesis, autoimmunity, and neurology projects in our R&ED pipeline.

Responsibilities will include, but are not limited to, the following:


Provide insights/expertise to the design of antibody discovery campaigns and lead identification
Design and conduct biochemical, biological, and flow cytometric assays to elucidate MOA, evaluate /refine bispecifics, and other antibody formats
Functional representation in antibody discovery programs in identifying therapeutics and appropriate surrogate tools for pharmacology studies and selection of candidates for lead optimization and nomination
Generate reason-to-believe data to initiate new project opportunities - c onduct, and supervise laboratory personnel in designing and execution of screening assays
Present data and updates to project teams or thematic research centers
Manage collaborations/CROs or internal research studies for antibody discovery and maturation
When needed, author section reports and data management to support IND/CTA filings


Requirements :


Ph.D. in Protein Sciences, Molecular Biology, Cell biology, Immunology or related field and at least 6 years experience in biologics drug discovery in biotech/pharmaceutical industry
Expertise in antibody discovery platforms (displays systems, rodents or other species, NGS etc.)
Broad experience in antibody expression and purification
Familiarity in cell cytometry, sorting, and imaging is desired
Broad understanding of Fc effector function modulation with applicable experience
Able to work independently as well as in a multi-discipline team environment
Ability to interface with business partners - effective communication and interpersonal skills
Ability to multi-task, handle multiple projects at one time, and change priorities based on business needs and competitive intelligence
Excellent written and oral communication skills
Ability to embrace a culture of continuous learning and improvement, increasing technical skill base and disease biology expertise
Track record in scientific publications


Around the world, we are passionate about making an impact on the lives of patients with serious diseases. Empowered to apply our individual talents and diverse perspectives in an inclusive culture, our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.

Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives.

Company: Bristol-Myers Squibb

Req Number: R1527690_EN

Updated: 2020-07-15 00:00:00.000 UTC

Location: San Diego,California

Bristol Myers Squibb is an equal opportunity employer. Qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, disability, protected veteran status, pregnancy, citizenship, marital status, gender expression, genetic information, political affiliation, or any other characteristic protected by law.

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